The side effects of platinum-based chemotherapy drugs: a review for chemists

    January 2018 in “Dalton transactions
    Rabbab Oun, Yvonne E. Moussa, Nial J. Wheate
    TLDR Platinum-based chemotherapy drugs can cause many severe side effects, often requiring dose reductions and additional medications to manage.
    The review from 2018 discussed the severe side effects associated with the use of platinum-based chemotherapy drugs cisplatin, carboplatin, and oxaliplatin, which are effective in cancer treatment but can cause around 40 different adverse effects. The primary dose-limiting side effects identified were nephrotoxicity for cisplatin, myelosuppression for carboplatin, and neurotoxicity for oxaliplatin. Other common side effects included anaphylaxis, various cytopenias, hepatotoxicity, ototoxicity, cardiotoxicity, gastrointestinal issues, mucositis, pain, alopecia, anorexia, cachexia, and asthenia. These side effects often necessitate dose reductions of 25 to 100% and extensive patient monitoring. Additionally, patients frequently need co-prescribed medications to manage these side effects, such as antiemetics, antibiotics, myeloid growth factors, and various supplements and blockers.
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