The Roles of S100 Proteins and RAGE in Melanoma

The document discussed the increasing incidence of melanoma and highlighted the S100 protein family member S100B as a significant prognostic marker, particularly for stage IV melanoma, as incorporated into the AJCC melanoma staging system. High serum levels of S100B were associated with poor survival rates, and its prognostic value in earlier melanoma stages was under investigation. The role of S100B in melanoma progression, including tumor development, invasion, and metastasis, was not fully understood, and the document explored the relationship between S100 proteins and their receptor, RAGE, in melanoma biology.