The first clinical experience on efficacy of topical flutamide on melasma compared with topical hydroquinone: a randomized clinical trial

August 2015 in “ Drug Design Development and Therapy ”

Homayoun Sadeghi‐Bazargani, Hassan Edalatkhah

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research A Review of Hormonal Therapy for Female Pattern (Androgenic) Alopecia

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Hormonal therapies like cyproterone acetate and spironolactone may help some women with hair loss, but finasteride 1mg is not useful, and the effectiveness of other treatments is still unclear.

research Comparison of Flutamide and Spironolactone in the Treatment of Hirsutism: A Randomized Controlled Trial

165 citations , February 1994 in “Fertility and Sterility”

Flutamide is more effective and has fewer side effects than spironolactone for treating hirsutism.

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Treating melasma in men is difficult, especially for the deeper skin layers, and may need more than just topical treatments.