The Contribution of the Intestinal Microbiota to Celiac Disease Pathogenesis and the Effectiveness of Probiotic Therapy

    November 2023 in “ Microorganisms ”
    O. Yu. Zolnikova, Natiya Dzhakhaya, Е. Л. Буеверова, А. В. Седова, А. А. Курбатова, Kira Kryuchkova, Tatiana V. Butkova, Alexander Izotov, Ludmila Kulikova, Kseniya A. Yurku, Pavel A. Chekulaev, Victoria Zaborova
    TLDR Probiotics may help manage celiac disease by improving gut health and reducing symptoms.
    The document reviews the role of intestinal microbiota in celiac disease (CD) pathogenesis and the potential of probiotic therapy. It highlights that alterations in gut microbiota, such as increased Bacteroidetes and Proteobacteria and decreased Lactobacillus and Bifidobacterium, are linked to CD. Factors like cesarean delivery and antibiotic use may increase CD risk by altering microbiota. Probiotics, particularly those with Lactobacillus and Bifidobacterium, show promise in maintaining intestinal barrier integrity and reducing symptoms, as supported by a meta-analysis of 5279 participants. Probiotics may also help break down gluten, reducing its immunotoxicity, but further research is needed to optimize treatments.
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