Effect of Thalidomide Combined with CHOP on Patients with Peripheral T-Cell Lymphoma
February 2020
in “
Central Plains Medical Journal
”
Studysummary In this study, combining thalidomide with CHOP treatment showed a significantly higher effective rate in treating peripheral T-cell lymphoma compared to CHOP alone, while both regimens were associated with similar levels of adverse reactions.
Our plain-language summary. Not medical advice or a treatment recommendation. Consult a qualified healthcare professional before changing treatment. Full disclaimer
The study investigated the clinical effects of combining thalidomide with the CHOP regimen (cyclophosphamide, doxorubicin, vincristine, and prednisone) in treating peripheral T-cell lymphoma. Conducted at Liaocheng People's Hospital, the study involved 72 patients divided into two groups: one receiving only CHOP and the other receiving CHOP plus thalidomide. After 8 treatment cycles, the group receiving thalidomide showed a higher overall effectiveness rate (86.11%) compared to the CHOP-only group (63.89%), with significant reductions in levels of arginase-1, VEGF, and iNOS. Importantly, the addition of thalidomide did not increase the incidence of adverse reactions, suggesting that thalidomide combined with CHOP was a more effective treatment option without additional side effects.
