Immunohistological Effects of Transforming Growth Factor-Beta via Platelet-Rich Plasma on Segmental Bone Defects: An Animal Study

    January 2021 in “ TURKISH JOURNAL OF VETERINARY AND ANIMAL SCIENCES ”
    Aziz Atik, Serdar Sargın, Gökhan Meriç, Cengiz Ceylan
    TLDR Platelet-rich plasma speeds up bone healing and reduces complications.
    This study investigated the effects of transforming growth factor-ß via platelet-rich plasma (PRP) on segmental bone defects in 10 adult New Zealand rabbits. PRP was applied to one leg of each rabbit, while the other leg served as a control. After six weeks, radiological and immunohistological assessments showed that the PRP group had a higher mean fracture healing score (3.2) compared to the control group (1.3). The PRP group exhibited more advanced stages of bone development, indicating that PRP administration enhanced bone union and reduced healing time, suggesting it could be a cost-effective treatment with fewer complications for segmental bone defects.
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