Tea Polyphenol–Zinc Nanocomplexes Alleviate Diquat-Induced Liver and Small Intestine Oxidative Stress in C57BL/6 Mice

The study investigates the effects of tea polyphenol–zinc (Tp-Zn) nanocomplexes on oxidative stress induced by diquat in C57BL/6 mice. Tp-Zn was shown to significantly improve intestinal barrier function and mitigate liver inflammation and damage. This was evidenced by the prevention of down-regulation of tight junction proteins and reduced serum levels of liver enzymes. Additionally, Tp-Zn enhanced antioxidant responses by up-regulating antioxidant enzyme expression and reducing oxidative markers like Malondialdehyde (MDA) and reactive oxygen species (ROS). The study suggests that metal–polyphenol coordination could be a promising strategy for addressing oxidative stress-related diseases.