Approved Systemic Drugs Needed for Dermatosis Like Alopecia Areata, Hidradenitis, and Vitiligo: A SPIN-FRT Evaluation

November 2024 in “ Journal of the European Academy of Dermatology and Venereology ”

Phyllis I. Spuls, Antonios G.A. Kolios, Marlide Jukema, Jürgen Burg, Carsten Flohr, Amit Garg, Nanja van Geel, Dmitri Wall, Nicolò Costantino Brembilla, Tiago Torres, Wolf‐Henning Boehncke

alopecia areata hidradenitis suppurativa vitiligo systemic treatments immune-mediated inflammatory diseases psoriasis atopic dermatitis Skin Inflammation and Psoriasis International Network AA HS VT PsO AD SPIN

TLDR More effective treatments are needed for alopecia areata, hidradenitis suppurativa, and vitiligo.

The document highlights the need for improved systemic treatments for chronic cutaneous immune-mediated inflammatory diseases (IMIDs) such as alopecia areata (AA), hidradenitis suppurativa (HS), and vitiligo (VT). While significant progress has been made in treating psoriasis (PsO) and atopic dermatitis (AD), with 19 and 7 approved systemic treatments respectively, there are only 3 approved treatments for both HS and AA, and none for VT. The SPIN (Skin Inflammation and Psoriasis International Network) emphasizes the importance of addressing these unmet needs by developing more evidence-based guidelines and innovative therapies. The document also stresses the necessity of incorporating patient perspectives into clinical research and the importance of real-world data to inform treatment guidelines.

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Research cited in this study

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research European Expert Consensus Statement on the Systemic Treatment of Alopecia Areata

4 citations, January 2024 in “JEADV. Journal of the European Academy of Dermatology and Venereology/Journal of the European Academy of Dermatology and Venereology”

Baricitinib and ritlecitinib are recommended for severe alopecia areata, with other treatments available off-label.

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research Twenty Nail Dystrophy with Alopecia Areata in an Atopic Child

April 2019 in “International journal of research in dermatology”

A child with rough nails also had hair loss and allergies.