Synaptic Relationships Between Hair Follicle Afferents and Neurons Expressing GABA and Glycine-Like Immunoreactivity in the Spinal Cord of the Rat

    September 2002 in “ The Journal of Comparative Neurology ”
    A. H. D. Watson, David I. Hughes, Ayoub A. Bazzaz
    TLDR Glycine likely affects dendrites connected to hair follicle terminals in rats.
    The study investigated the synaptic interactions between hair follicle afferent terminals and neurons expressing GABA and glycine-like immunoreactivity in the spinal cord of rats. It was found that 94% of afferent boutons were postsynaptic at axo-axonic synapses, with 67% of presynaptic boutons being immunoreactive for both GABA and glycine, 24% for GABA alone, and 7% for glycine alone. A small percentage of dendrites postsynaptic to afferent boutons were immunoreactive for inhibitory neurotransmitters, with 3% for both GABA and glycine, 10% for glycine alone, and 87% for neither. The study suggested that glycine might act on dendrites postsynaptic to hair follicle afferent terminals, as these terminals do not express glycine receptors themselves.
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