Surface Engineered Metal-Organic Frameworks (MOFs) Based Novel Hybrid Systems for Effective Wound Healing: A Review of Recent Developments

The review discussed the potential of surface-engineered metal-organic frameworks (MOFs) in enhancing wound healing processes due to their high surface area, biocompatibility, and ability to load and release therapeutic agents. MOFs were highlighted for their intrinsic antibacterial and angiogenic properties, which were beneficial in wound care. The review emphasized the advantages of MOFs over traditional wound treatments, such as promoting cell proliferation, angiogenesis, and collagen deposition, while offering targeted delivery and controlled release of therapeutic agents. Studies demonstrated the effectiveness of MOFs in treating bacterial infections in wounds, with examples including MOFs with photodynamic and photothermal therapy capabilities, and those functionalized with silver nanoparticles or copper ions for enhanced antibacterial effects. These engineered MOFs showed promising results in animal models, promoting wound healing without significant toxicity. Despite these advancements, no surface-modified MOFs systems had entered clinical trials by 2020, indicating the need for further research to explore their potential in human applications.