Structural Basis of Malodour Precursor Transport in the Human Axilla

    March 2018
    TLDR The study identified a key protein involved in producing underarm odor and found ways to inhibit it.
    The study identified and determined the crystal structure of a transporter protein for S-Cys-Gly-3M3SH in Staphylococcus hominis, which is involved in producing underarm odor. Using E. coli for genetic manipulation, the researchers conducted transport and functional assays, finding that di- and tripeptides inhibit 3M3SH production, supporting the role of the SH1446 protein as the major transporter. They highlighted the adaptability of the binding site within the POT family of transporters and calculated a turnover number of approximately 10 per minute for the wild-type transporter. The study noted limitations due to the inability to genetically manipulate S. hominis and the need for further verification of the transporter's turnover rate.
    Discuss this study in the Community →

    Related Community Posts Join

    6 / 1000+ results

      community It's so over. Im beyond cooked

      in Update 3 days ago
      The user is experiencing hair loss despite using Dutasteride and plans to try RU58841, considering adding Oral Minoxidil. They express frustration with diffuse thinning and seek advice on managing hair loss.

      community It's always the Mice that gets to grow back hair.

      in Research/Science  429 upvotes 2 weeks ago
      Sodium dodecyl sulfate, oleic acid, and palmitoleic acid may promote hair growth, but their safety and effectiveness for humans are uncertain. Users consider trying these treatments cautiously, exploring alternatives like ostrich oil and microneedling.

      community Let's talk about the use of minoxidil 15%

      in Minoxidil  3 upvotes 3 weeks ago
      Minoxidil 5% is no longer effective for the user, who is considering stronger minoxidil or oral options despite availability issues. Suggestions include trying minoxidil 15%, oral minoxidil, microneedling, and exploring other treatments like finasteride and dutasteride.

      community What’s the best microneedling protocol?

      in Microneedling  9 upvotes 1 month ago
      Microneedling for hair loss involves using a derminator pen at a depth of 1-1.5mm, typically once a week or biweekly, with a 12-24 hour wait before applying minoxidil. Cleaning involves alcohol wipes, and it's advised to change needles after each use and avoid styling products on the day of microneedling.

      community Let's talk keratin products and hair loss

      in Styling  2 upvotes 1 month ago
      OP is considering using a keratin gel to improve hair quality and is concerned about its safety and visual impact on a slightly balding crown. Users discuss shampoo frequency, with some suggesting less frequent use for better hair health, but OP prefers regular shampoo and conditioner for silky hair.

    Similar Research

    5 / 1000+ results