Is Polymorphism of the STK11 Gene a Predictor of Response to Metformin in Polycystic Ovarian Syndrome?

The study on 57 women with polycystic ovary syndrome (PCOS) examined whether STK11 gene polymorphisms predict the response to metformin treatment. Metformin significantly improved menstrual regularity, reduced menstrual blood loss, acne, and hirsutism, and decreased body weight and BMI, but did not significantly affect alopecia. Different subgroups of STK11 polymorphisms (Intron 1 and Intron 6) showed varied responses, but overall, STK11 polymorphism was not predictive of metformin response. The study concludes that while metformin is effective for several PCOS symptoms, larger studies are needed to understand the role of STK11 polymorphisms.