TLDR STK11 gene polymorphism does not predict metformin response in PCOS.
The study on 57 women with polycystic ovary syndrome (PCOS) examined whether STK11 gene polymorphisms predict the response to metformin treatment. Metformin significantly improved menstrual regularity, reduced menstrual blood loss, acne, and hirsutism, and decreased body weight and BMI, but did not significantly affect alopecia. Different subgroups of STK11 polymorphisms (Intron 1 and Intron 6) showed varied responses, but overall, STK11 polymorphism was not predictive of metformin response. The study concludes that while metformin is effective for several PCOS symptoms, larger studies are needed to understand the role of STK11 polymorphisms.
2 citations
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September 2016 in “Journal of skin and stem cell” Acne is strongly linked to high BMI, hair loss, menstrual issues, family history, and eating too many sweets and fatty foods, but not to excessive hair growth.
14 citations
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February 2016 in “Journal of Obstetrics and Gynaecology Research” Blood tests are needed to confirm high male hormone levels in women with PCOS, as physical signs alone are not reliable.
11 citations
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August 2014 in “PubMed” Women with acne often have higher levels of male hormones and are more likely to be overweight, both of which can make acne worse.
3 citations
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January 2012 in “Hanyang Medical Reviews” The document concludes that more research is needed to create suitable diagnostic criteria and understand PCOS in Korean women, and genetics may allow for personalized treatment.
85 citations
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June 2006 in “Best Practice & Research Clinical Endocrinology & Metabolism” The document concludes that hirsutism is the main sign for diagnosing hyperandrogenism, which requires a detailed patient history and physical exam.
1 citations
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April 1993 in “Problemy e̊ndokrinologii”
