Steroid sulfatase inhibitors

The document reviewed the role of steroid sulfatase (STS) in regulating local estrogen and androgen production, highlighting its potential as a therapeutic target for estrogen- and androgen-dependent disorders, including cancers and androgenetic alopecia. It discussed the development of STS inhibitors, focusing on their structure-activity relationships and the discovery of both irreversible arylsulfamate-based inhibitors and novel reversible inhibitors. The publication of the X-ray structure of STS was expected to enhance research efforts in this area.