Steroid-Sparing Effect of Mycophenolate Mofetil in the Treatment of a Subepidermal Blistering Autoimmune Disease in a Dog: Clinical Communication

A 7-year-old female Cocker spaniel-cross with an 8-month history of mucocutaneous erosive dermatitis was diagnosed with autoimmune subepidermal blistering dermatosis. Treatment with oral prednisone (2 mg/kg) and mycophenolate mofetil (MMF) (20 mg/kg twice daily) led to the resolution of ulcers and erosions within 4 weeks. MMF was then maintained at 10 mg/kg twice daily, allowing prednisone to be tapered to 0.25 mg/kg every other day without recurrences. This case indicated that MMF was well tolerated and potentially effective as a steroid-sparing agent for long-term management of this condition.