Smart DNA Biosensor for In Vitro Detection of Androgen Receptor mRNA

    January 2020
    Ekaterina A. Bryushkova, Erik Gandalipov, Julia Victorovna Nuzhina
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    TLDR A new easy-to-use biosensor was made to detect androgen receptor mRNA, which could help diagnose related conditions quickly.
    In 2020, a novel Smart DNA Biosensor was developed for the primary diagnosis of androgen receptors overexpression, which can lead to conditions such as acne, androgenetic alopecia, or hirsutism. This biosensor, based on RNA-dependent split aptamer, was found to be easy to use, highly efficient and selective, and due to its modular structure, could be easily optimized for the detection of various targets. This development suggested that such sensors could be useful for rapid differential diagnosis, particularly in cases where traditional laboratory techniques are not available due to their complexity and laboriousness.
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