Skin and hair regeneration after calciphylaxis. Histologic changes during formation and shedding of the calciphylactic carapace of the rat

The study conducted in 1969 on rats demonstrated that during localized calciphylaxis, the calcified carapace did not encompass the entire skin, allowing for some regeneration from the remaining connective tissue and epithelium. However, this regeneration was incomplete and resembled scar tissue, lacking restored elastic fibers and showing a significant reduction in hair numbers. It was unclear whether the regrowth of hair was due to surviving hair roots or new hair formation. Additionally, there was a notable increase in calcium in growing hairs and a lack of alcian blue stainable substances in mast cell granules post-calciphylaxis.