Single-Administration Long-Acting Microarray Patch with Ultrahigh Loading Capacity and Multiple Releases of Thermally Stable Antibodies

Researchers have developed a novel microarray (MA) patch for single-administration, long-lasting antibody delivery, capable of carrying high doses of thermally stabilized antibodies. This MA patch, created using additive three-dimensional manufacturing technology, can be embedded into the skin to deliver antibodies at multiple programmable time points, maintaining their concentration in systemic circulation. The study demonstrated that the patch could stabilize and deliver human immunoglobulins (hIg) while preserving their structure and functionality. Specifically, the b12 antibody, effective against HIV-1, retained its antiviral activity after manufacturing and heat exposure. Pharmacokinetic studies in rats confirmed the concept of concurrent and time-delayed antibody delivery, suggesting that these MA patches could be used for expanded viral infection protection or combination HIV therapy and prevention.