Pathology in Practice: Sebaceous Gland Dysplasia in Persian Cats

    June 2018 in “ Journal of the American Veterinary Medical Association ”
    Ana Canadas, Carlos M.P. Sousa, Patrícia Dias‐Pereira
    TLDR Three related Persian cats have a rare, likely hereditary skin condition causing hair loss and poor coat quality, with limited treatment options.
    Three related Persian cats, including a sire and two kittens, exhibited alopecia, hyperpigmentation, scales, and crusts from a young age, unresponsive to broad-spectrum treatments. A 5-month-old female kitten was evaluated, showing generalized hypotrichosis and severe periocular crusting. Histopathological examination revealed sebaceous gland dysplasia, characterized by atrophy and abnormal sebaceous gland morphology. This rare congenital dermatosis, likely hereditary, involves nonpruritic hypotrichosis and poor coat quality. Diagnosis requires skin biopsy, and while complete recovery is unlikely, topical treatments and supplements may offer some improvement. The condition's etiology remains unclear, with potential links to genetic factors and in utero environmental influences.
    Discuss this study in the Community →

    Research cited in this study

    1 / 1 results

    Related Community Posts Join

    6 / 1000+ results

      community Does finasteride/dutasteride reverse aging?

      in Chat  45 upvotes 1 month ago
      Finasteride and dutasteride can improve skin texture and reduce acne by lowering DHT but do not reverse aging. They may enhance skin and hair health for some, but can also cause side effects like dry skin and sexual dysfunction.

      community I am a dermatologist with a clinical interest in alopecia. AMA

      in Will treatment work for me? 2 years ago
      In this conversation, 4990 discussed various treatments for hair loss, including oral minoxidil, PRP, transplan, Jak inhibitors, Dutasteride, Finasteride, Olumiant, Ketoconazole, RU58841, microneedling, baricitinib, and CCCA. They recommended scalp biopsies in unclear cases of DUPA, twice weekly to twice daily shampooing for topical minoxidil users, and two sessions spaced one month apart with follow up at month three to determine the effectiveness of PRP treatment.

      community What are these spots on my scalp

      in Treatment  51 upvotes 4 months ago
      A user noticed non-itchy, non-bleeding spots on their scalp while experiencing hair loss. Replies suggest the spots are likely sunspots or liver spots and recommend seeing a dermatologist; hair loss is attributed to male pattern baldness.

      community Why is no one pointing out dandruff as the number 1 evidence/symptom of MPB?

      in Chat  55 upvotes 1 year ago
      The post discusses the theory that persistent dandruff in areas prone to hair loss could be a sign of hair follicles dying due to DHT, indicating balding. The responses vary, with some users noting improvements in dandruff and hair loss with treatments like Dutasteride, while others experienced hair loss without dandruff.

      community Comprehensive Microneedling Guide

      in Microneedling  295 upvotes 2 years ago
      Microneedling for hair restoration involves daily use of a 0.3 mm device and weekly use of a 0.5 mm device. Combining microneedling with Minoxidil can enhance hair growth.

    Similar Research

    5 / 1000+ results
      Noninflammatory, Nonpruritic Alopecia of Horses

      research Noninflammatory, Nonpruritic Alopecia of Horses

      5 citations, October 2013 in “Veterinary Clinics of North America: Equine Practice”
      Some horses lose hair without inflammation or itching due to various conditions, and while mainly a cosmetic issue, diagnosis requires examination and biopsies, and breeding is not advised if it's hereditary.
      Index

      research Index

      November 2019 in “Harper's Textbook of Pediatric Dermatology”
      The document is a detailed medical reference on skin and genetic disorders.
      Follicular Dysplasia in Five Weimaraners

      research Follicular Dysplasia in Five Weimaraners

      18 citations, October 2002 in “Veterinary dermatology”
      Five Weimaraners had a milder form of color dilution alopecia causing hair loss and skin issues.
      Diseases of the Ear Pinna

      research Diseases of the Ear Pinna

      1 citations, August 2012
      The document discusses various diseases of the outer ear, categorized by symptoms like redness, crusts, bumps, pus-filled lesions, lumps, ulcers, and hair loss.
      Madarosis: A Marker of Many Maladies

      research Madarosis: A Marker of Many Maladies

      36 citations, January 2012 in “International Journal of Trichology”
      Losing eyelashes or eyebrows can be a sign of many different health problems and needs a careful approach to treat effectively.