Preparation and Characterization of Rutin-Loaded Nanophytosomes

    November 2015 in “ Pharmaceutical Sciences ”
    Zahra Hooresfand, Saeed Ghanbarzadeh, Hamed Hamishehkar
    TLDR Nanophytosomes can improve the delivery and effectiveness of herbal medicines like Rutin.
    The study aimed to improve the bioavailability and antioxidant properties of Rutin, a phenolic antioxidant with poor oral absorption, by preparing a Rutin-loaded nanophytosomal formulation. Using phosphatidylcholine and cholesterol, the researchers developed nanophytosomes through a thin layer hydration method. The formulation with a Rutin: PC molar ratio of 1:2 exhibited the smallest particle size, and the addition of cholesterol enhanced the physical stability of the nanophytosomes for over three weeks. FTIR and DSC analyses confirmed the formation of a Rutin-phospholipid complex. The study concluded that nanophytosomes could serve as effective carriers for enhancing the delivery of herbal medicinal compounds in food and pharmaceutical products.
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