Preparation and Characterization of Rutin-Loaded Nanophytosomes

The study aimed to improve the bioavailability and antioxidant properties of Rutin, a phenolic antioxidant with poor oral absorption, by preparing a Rutin-loaded nanophytosomal formulation. Using phosphatidylcholine and cholesterol, the researchers developed nanophytosomes through a thin layer hydration method. The formulation with a Rutin: PC molar ratio of 1:2 exhibited the smallest particle size, and the addition of cholesterol enhanced the physical stability of the nanophytosomes for over three weeks. FTIR and DSC analyses confirmed the formation of a Rutin-phospholipid complex. The study concluded that nanophytosomes could serve as effective carriers for enhancing the delivery of herbal medicinal compounds in food and pharmaceutical products.