A Validated RP-HPLC Method to Investigate Finasteride in Human Skin After In Vitro Topically Applying Vesicular Nanocarrier

May 2014 in “ PubMed ”

Feiyue Zheng, Yuefeng Rao, Yan Lou, Xiaoyang Lu

finasteride RP-HPLC vesicular nanocarrier EclipseXDB-C18 column liposomal carriers ethosomal carriers percutaneous delivery Propecia

TLDR The method accurately measures finasteride in skin after using special carriers.

The study developed a sensitive and validated RP-HPLC method to measure finasteride distribution in human cadaver skin after applying vesicular nanocarrier formulations. Using an EclipseXDB-C18 column, the method achieved a linear standard-calibration curve within 5 to 200 ng/ml, with a correlation coefficient of 0.9996. The intra-assay and inter-assay precision were less than 3.9% and 7.1%, respectively, with a bias range of -8.6 to 4.1%. This method was specific, accurate, and sensitive, effectively determining finasteride accumulation in skin layers following in-vitro percutaneous delivery via liposomal or ethosomal carriers.

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