Determination of Residual Organic Solvents in Finasteride by Headspace Capillary Gas Chromatography

January 2007 in “ Journal of Instrumental Analysis ”

Cao Shu-wen

finasteride chloroform dichloromethane Propecia

TLDR A new method accurately detects tiny amounts of chloroform and dichloromethane in finasteride.

The study developed a method using headspace capillary gas chromatography to determine residual organic solvents, specifically chloroform and dichloromethane, in finasteride. The method effectively separated the solvent peaks and demonstrated excellent linearity with correlation coefficients of 0.9997 and 0.9998. The detection limits were 3.2 μg/L for chloroform and 0.094 μg/L for dichloromethane, with relative standard deviations (RSDs) of 1.33% and 0.89%, respectively. Factors such as equilibrium times, equilibrium temperature, and salting-out were also examined to optimize the method.

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research Determination of Residual Organic Solvents in Finasteride Raw Materials by Headspace Capillary Gas Chromatography

January 2013 in “Zhongguo yaofang”

The method effectively detects residual solvents in finasteride raw materials.