Rejuvenation: an integrated approach to regenerative medicine

The document discussed the potential of rejuvenating the body's self-repair mechanisms as an alternative approach to regenerative medicine, highlighting the challenges faced by traditional methods like transplantation and cell therapy due to integration issues and the need for lifelong immunosuppression. It emphasized the body's inherent self-repair capabilities, which were more active in younger individuals and under acute injury conditions but suppressed in older individuals and chronic injuries. The review explored the role of tissue injury signaling systems and the importance of reestablishing communication systems, particularly the vascular system, for effective tissue repair. It also highlighted the role of progenitor and stem cells in tissue repair and regeneration, noting the difference between repair and regeneration. The study of kidney regeneration identified a crucial molecular pathway, Wnt7b, and suggested that integrating rehabilitation with regenerative medicine could enhance outcomes. The document concluded that rejuvenating self-regeneration mechanisms could improve functional recovery, requiring a deep understanding of developmental biology and innovative approaches.