Registrars’ Symposium: Summaries of Papers

June 2006 in “ British Journal of Dermatology ”

diffuse generalized hair loss postmenopausal women DHEAS adrenal androgens

TLDR Lower adrenal hormone levels may cause hair loss in postmenopausal women, certain patterns help diagnose nail cancer, and a gene variant linked to higher skin cancer risk in kidney transplant patients suggests monitoring folate levels.

The document summarizes three studies: the first study found that 14% of postmenopausal women experienced diffuse generalized hair loss, which was linked to lower levels of DHEAS but not to testosterone or SHBG, indicating a potential role for adrenal androgens in hair loss. The second study analyzed 20 cases of nail unit SCC over 8 years, identifying three characteristic patterns and underscoring the need for better recognition for timely diagnosis. The third study discovered a significant association between the MTHFR 677T allele and an increased risk of SCC in renal transplant patients, suggesting the importance of folate status monitoring in this population.

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