Reactive oxygen species–degradable polythioketal urethane foam dressings to promote porcine skin wound repair

    April 2022 in “ Science Translational Medicine ”
    Prarthana Patil, Katherine A. Russo, Joshua T. McCune, Alonda C. Pollins, Matthew A. Cottam, Bryan R. Dollinger, Carlisle R. DeJulius, Mukesh Kumar Gupta, Richard d’Arcy, Juan M. Colazo, Fang Yu, Mariah G. Bezold, John R. Martin, Nancy L. Cardwell, Jeffrey M. Davidson, Callie M Thompson, Adrian Barbul, Alyssa H. Hasty, Scott A. Guelcher, Craig L. Duvall
    TLDR The EG7 foam dressing improved wound healing and reduced inflammation better than other treatments.
    The study explored reactive oxygen species (ROS)-degradable polythioketal (PTK) urethane (UR) foams with varying hydrophilicity for skin wound healing in porcine models. The most hydrophilic variant, EG7, demonstrated the highest ROS reactivity and promoted optimal tissue infiltration, extracellular matrix deposition, and reepithelialization. EG7 also induced a lower foreign body response, greater recruitment of regenerative immune cells, and resolution of type 1 inflammation compared to more hydrophobic PTK-UR scaffolds. Compared to NovoSorb Biodegradable Temporizing Matrix (BTM) and Integra Bilayer Wound Matrix (BWM), EG7-treated wounds showed greater ECM production, vascularization, and resolution of proinflammatory immune cells, as well as higher wound healing scores in an ischemic flap excisional wound model. The findings suggested that PTK-UR foams, particularly the EG7 variant, warranted further investigation as synthetic biomaterials for wound healing applications.
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