Rapidly Worsening Subcutaneous Edema in a Young Boy: A Case of Juvenile Dermatomyositis

    April 2022 in “ Rheumatology ”
    Shalini Janagan, W. A. E Udeshika, Pasindu M Samarasinghe, Jayatri Jagoda
    Image of study
    TLDR Juvenile dermatomyositis can worsen quickly and needs strong treatment.
    A 4-year-old boy in Sri Lanka presented with generalized rash, facial puffiness, hair loss, and muscle weakness, leading to a diagnosis of juvenile dermatomyositis (JDM). Despite initial treatment with high-dose steroids, his condition worsened with severe subcutaneous edema and muscle power deterioration. Further treatment with IV Methylprednisolone, plasmapheresis, and cyclophosphamide led to improvement, though he remains steroid-dependent and awaits Rituximab treatment. The case highlights the severe, rapidly progressive nature of JDM-associated subcutaneous edema and the need for aggressive immunosuppression for better outcomes.
    Discuss this study in the Community →

    Related Community Posts Join

    6 / 1000+ results

      community Hair loss treatments rated (by gpt-4)

      in Research/Science  253 upvotes 1 year ago
      Rating treatments for hair loss, with the help of GPT-4, according to efficacy, evidence and tolerability; a combination of chemicals from research papers, custom compounds, and some suggestions from other users were included.

      community New potential hair loss treatment (news release)

      in Treatment  186 upvotes 4 years ago
      New potential hair loss treatment uses molecules from hairy moles to stimulate follicle growth. Topical solution requires less frequent application, like Botox injections a few times per year.

      community When did you know it was time to intervene in your hair loss? The truth hurts, but it’s good for someone to be up front with you

      in Chat  54 upvotes 1 year ago
      A person realized they were balding when their sister pointed it out and is now using a combination of hair loss treatments including finasteride, minoxidil, microneedling, and plans to add dutasteride and RU58841. Others in the conversation emphasize the importance of honesty about hair loss and caution against an overly aggressive treatment regimen, especially before a hair transplant.

      community Genetics are so weird and unpredictable

      in Minoxidil  118 upvotes 1 month ago
      The user experienced male pattern baldness starting at 18, tried finasteride with no success, and switched to dutasteride, which halted hair loss. Minoxidil had no effect for them, while their brother, who didn't use AR inhibitors, maintained a juvenile hairline and successfully grew a beard with minoxidil, highlighting the unpredictable nature of genetics in hair loss and treatment response.

    Similar Research

    5 / 1000+ results
      Index

      research Index

      November 2019 in “Harper's Textbook of Pediatric Dermatology”
      The document is a detailed medical reference on skin and genetic disorders.
      Wound Healing and Hair

      research Wound Healing and Hair

      July 2003 in “Journal of Cutaneous Medicine and Surgery”
      Certain drugs can cause lupus, stopping these drugs is the main treatment. NB-UVB phototherapy clears psoriasis faster when applied three times a week. Monoclonal antibodies and oral pimecrolimus are effective in treating psoriasis. Smoking and drinking are linked to psoriasis in men. No direct link between low iron and hair loss was found. Vaccines are effective against genital herpes and human papillomavirus type 16.
      Medical Practice: Therapy and Adverse Reactions

      research Medical Practice: Therapy and Adverse Reactions

      July 2003 in “Journal of Cutaneous Medicine and Surgery”
      Blood pressure drugs can cause skin lupus, but it improves after stopping the drug. The glycoprotein D vaccine works against genital herpes in some women, and the HPV-16 vaccine reduces HPV-16 infection and related diseases. More frequent light therapy clears psoriasis faster. A cream called imiquimod effectively treats a type of skin cancer. Iron supplements don't necessarily help with chronic hair loss in women.
      Internal Medicine: Retrospective Review of 120 Patients Over a 10-Year Period

      research Internal Medicine: Retrospective Review of 120 Patients Over a 10-Year Period

      July 2003 in “Journal of Cutaneous Medicine and Surgery”
      Certain drugs can cause skin lupus, but stopping the drug usually helps. Vaccines work against smallpox, genital herpes, and a type of human papillomavirus. More frequent light therapy clears psoriasis faster. Certain treatments work for psoriasis and dermatitis. A specific cream effectively treats a type of skin cancer. Low iron levels aren't directly linked to chronic hair loss.