Decoding Pumpkin Seeds for Hair Loss: A Computational Perspective

July 2023 in “ Zenodo (CERN European Organization for Nuclear Research) ”

Kashif Abbas, Mudassir Alam, Tanjeem Raza, S Mohd. Hasan Abedi

pumpkin seed compounds androgenetic alopecia 5-alpha-reductase testosterone dihydrotestosterone DHT ADME/T analysis AGA

TLDR Pumpkin seeds may help treat hair loss by blocking a key enzyme.

The study explores the potential of pumpkin seeds as a natural remedy for androgenetic alopecia (AGA) by focusing on the inhibition of the enzyme 5-alpha-reductase, which converts testosterone into dihydrotestosterone (DHT), a key factor in hair loss. Through virtual simulations and ADME/T analysis, the research evaluates the interactions between active compounds in pumpkin seeds and the 5-alpha-reductase enzyme. The findings aim to provide insights into the effectiveness of pumpkin seeds as a therapeutic option for AGA by examining protein-ligand interactions computationally.

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