Differential Associations of Psoriasis Subtypes With Autoimmune Disorders in US Children and Adults: A Cross-Sectional Study

The study analyzed data from the National Emergency Department Sample (NEDS) from 2015-2019, which included a 20% cross-sectional sample of US emergency department visits (142,715,425 visits). It found that the prevalence of at least one autoimmune disease was significantly higher in patients with all psoriasis subtypes, including generalized pustular psoriasis (GPP), psoriasis vulgaris (PV), guttate psoriasis (GP), and palmoplantar pustular psoriasis (PPP), compared to those without psoriasis. Specifically, GP, GPP, and PV were associated with 8 of the 9 autoimmune disorders examined, including Crohn’s disease, vasculitis, and Sjogren's syndrome. Among emergency department patients with psoriasis, those with at least one autoimmune disorder were more likely to be female, aged 40-59 years, and have encounters in the spring. All psoriasis subtypes were associated with higher odds of multiple autoimmune diseases, but the profile of autoimmune disorders differed across psoriasis subtypes.