Assessment of the Effectiveness and Satisfaction of Platelet-Rich Plasma Compared with Hyaluronic Acid in Knee Osteoarthritis at Minimum 7-Year Follow-Up: A Post Hoc Analysis of a Randomized Controlled Trial

This study assessed the long-term effectiveness and patient satisfaction of platelet-rich plasma (PRP) versus hyaluronic acid (HA) injections for knee osteoarthritis over a mean follow-up of 78.9 months, with 85 out of 100 patients completing the follow-up. PRP showed a higher cumulative survival rate (90%) compared to HA (74%), with better clinical outcomes in terms of pain reduction and joint function. However, imaging evaluations showed no significant differences between the groups. Despite the promising results for PRP, the study noted limitations such as a small sample size and lack of PRP preparation guidelines, indicating a need for further research.