A Case of Proliferative and Membranous Lupus Nephritis Complicated by Cryoglobulin-like Hyaline Thrombi

February 2021

John Flores, Shiva Arami, Suman Setty

systemic lupus erythematosus lupus nephritis thrombotic microangiopathy cryoglobulin-like thrombi hair loss SLE LN TMA

TLDR Lupus nephritis can cause severe kidney and blood vessel problems.

A 21-year-old woman with systemic lupus erythematosus (SLE) and Class VI nephritis experienced worsening kidney function, indicated by a serum creatinine increase to 2.9 mg/dL. She presented with symptoms including shortness of breath, cough, headache, and hair loss, and had a blood pressure of 200/123. Despite compliance with her medications, her condition was complicated by thrombotic microangiopathy (TMA) and rare cryoglobulin-like thrombi. This case highlighted the severe renal and vascular complications that can arise in lupus nephritis (LN).

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