Premature Isolated Adrenarche in a Six-Year-Old Girl

June 2025 in “ V F Snegirev Archives of Obstetrics and Gynecology ”

Albina M Miftakhova, Daniil N. Bobkov, Elena A. Chulkova, Elena I. Nichaeva, Konstantin V. Mitrashov, Olga V. Krivenkova, Tatiana E. Navruzova, Maria A. Orluk

premature isolated adrenarche terminal hair dehydroepiandrosterone sulfate adrenal zona reticularis congenital adrenal hyperplasia central precocious puberty bone age polycystic ovary syndrome DHEA sulfate adrenal gland early puberty PCOS

TLDR A six-year-old girl has early signs of puberty, needs no treatment, but requires regular check-ups for future health risks.

The document presents a clinical case of premature isolated adrenarche in a 6-year-old girl, marked by early pubic hair development without other puberty signs. This condition is due to early adrenal cortex maturation and elevated DHEA-S levels. The case underscores the need for differential diagnosis to rule out conditions like congenital adrenal hyperplasia and androgen-producing tumors. The girl was diagnosed with isolated adrenarche, requiring no immediate treatment but necessitating ongoing monitoring for future risks such as polycystic ovary syndrome. Vitamin D supplementation is recommended, and the prognosis is generally favorable with regular follow-ups advised. The study stresses the importance of parental awareness and dynamic observation, with no funding or conflicts of interest reported.

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