Prehyperuricemia: New Milestone in Metabolic Disorders

The review article highlights the global increase in hyperuricemia, a metabolic disorder associated with non-communicable diseases (NCDs) due to dietary and lifestyle changes. It suggests that hyperuricemia should be diagnosed early as prehyperuricemia, akin to prediabetes and prehypertension, to prevent complications of related diseases. The document emphasizes early screening and lifestyle modifications to maintain safer uric acid levels and improve quality of life. It also discusses the molecular mechanisms of uric acid in systemic inflammation and NCD development, even without gout. Hyperuricemia is linked to cardiovascular disease, metabolic syndrome, diabetes mellitus, and other conditions. The review advocates for increased awareness and screening for high normal uric acid values to prevent symptomatic hyperuricemia or asymptomatic hyperuricemia with many NCDs.