Copious Pre-Ejaculation: Small Glands—Major Headaches

April 2007 in “ Journal of Andrology ”

Aleksander Chudnovsky, Craig Niederberger

dihydrotestosterone 5-alpha-reductase inhibitors finasteride dutasteride Cowper glands DHT Propecia Avodart bulbourethral glands

TLDR Excessive pre-ejaculation can be treated with certain medications.

The document discussed the issue of copious pre-ejaculation, a condition where excessive pre-ejaculate fluid is produced, causing social and physical distress. This fluid, produced by accessory sex glands like Cowper glands, serves to neutralize urine acidity and facilitate sperm passage. While excessive pre-ejaculate is often anecdotal, it was documented as a real concern. Some researchers suggested that the condition might be linked to dihydrotestosterone (DHT) sensitivity, and treatment with 5-α-reductase inhibitors, such as finasteride or dutasteride, showed success in resolving symptoms in several cases. The document also touched on the presence of HIV and debated the presence of sperm in pre-ejaculate, questioning the reliability of coitus interruptus as contraception.

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