Platelet Activation During PRP Preparation for Therapeutic Use
July 2024
in “
Journal of Investigative Dermatology
”
platelet-rich plasma androgenetic alopecia growth factor platelet-poor plasma non-activated PRP calcium chloride hepatocyte growth factor transforming growth factor beta1 vascular endothelial growth factor platelet-derived growth factor-AA brain-derived neurotrophic factor epidermal growth factor fibroblast growth factor 2 PRP A-PRP PPP HGF TGFβ1 VEGF PDGF-AA BDNF EGF FGF2
TLDR PRP preparation partially activates platelets, causing varied growth factor release.
This study investigated platelet activation during the preparation of platelet-rich plasma (PRP) for therapeutic use in 24 female patients with androgenetic alopecia. The researchers measured growth factor (GF) concentrations in platelet-poor plasma (PPP), non-activated PRP, and PRP activated with calcium chloride (A-PRP). They found that PRP preparation led to partial platelet activation, with significant secretion of hepatocyte growth factor (HGF) at 58% and transforming growth factor beta1 (TGFβ1) at 36%. Other growth factors like VEGF, PDGF-AA, and BDNF showed lower secretion levels, while EGF and FGF2 had minimal secretion, indicating the need for in-situ activation for their release. The study concludes that while PRP preparation induces some platelet activation, the secretion levels vary among different growth factors.
