Pili Torti in Association with Citrullinemia

January 1985 in “ Journal of the American Academy of Dermatology ”

Harikrishna P. Patel, Mark E. Unis

pili torti citrullinemia scalp hair loss

TLDR A girl with citrullinemia developed pili torti, suggesting a link between the hair condition and the metabolic disorder.

A 2.5-year-old white girl with citrullinemia and neurologic symptoms experienced a 2- to 3-week period of scalp hair loss, with 90% of her hairs broken off to less than 1 mm in length. Microscopic examination revealed the hairs were flattened, twisted 180 degrees, and broken at the twist points, leading to a diagnosis of pili torti. This rare hair disorder had not been previously associated with citrullinemia.

View this study on jaad.org →

Discuss this study in the Community →

Research cited in this study

1 / 1 results

research Arginosuccinic Aciduria in a 4-Year-Old Girl: Neurological Symptoms and Hair Abnormalities

10 citations, May 1974 in “American journal of diseases of children”

The girl had a rare disorder causing mental and physical symptoms, with weak hair and unclear neurological issues.

Related Community Posts Join

6 / 18 results

community Hair theory Scar tissue and Verteporfin

in Chat 26 upvotes 6 months ago

A user suggests that deeper microneedling with Verteporfin injections might help regrow hair in areas with scar tissue, alongside a DHT blocker. Another user explains that hair loss might be due to reduced Wnt/β-Catenin signaling and suggests that treatments like Minoxidil, Finasteride, and microneedling could potentially reverse it.

community Do hair follicles dies or are dormant ?

in Finasteride/Dutasteride 92 upvotes 4 weeks ago

Hair follicles can be dormant and potentially revived with treatments like finasteride and minoxidil, but irreversible loss occurs if certain structures are destroyed. Early intervention is more effective, and additional methods like microneedling may help.

community Physio-metabolic method of treating androgenic alopecia. Cold receptors. The relationship between DHT, cold receptors, minoxidil and antiandrogens.

in Research/Science 1 upvotes 2 weeks ago

A method for treating androgenic alopecia using minoxidil, antiandrogens, exercise, and cold exposure to promote hair growth. Environmental factors and lifestyle changes, like diet and exercise, can improve treatment effectiveness.

Physio-metabolic method of treating androgenic alopecia. Cold receptors. The relationship between DHT, cold receptors, minoxidil and antiandrogens

community Physio-metabolic method of treating androgenic alopecia. Cold receptors. The relationship between DHT, cold receptors, minoxidil and antiandrogens

in Research 411 upvotes 2 weeks ago

Treating androgenic alopecia with minoxidil, finasteride, and antiandrogens, alongside exercise, cryotherapy, and natural substances to stimulate cold receptors for better hair growth. The method focuses on enhancing treatment effectiveness by considering environmental and behavioral factors and the role of cold receptors and muscle stress.

community The Real Cause Of Androgenetic Alopecia

in Research/Science 667 upvotes 2 months ago

Androgenetic alopecia is caused by DHT affecting hair growth. Finasteride and minoxidil are used to manage hair loss by blocking DHT and promoting hair growth.

community HRT is literal black magic. Fin 1 mg/day @ 4 years, min 2x/day @ 3 years, Estradiol 4mg/day @ 3.5 months, and Spironolactone 100mg/day @ 3.5 months (estra & spiro are medicines you should likely not take if you are a cis man)

in Progress Pictures 118 upvotes 3 months ago

User shared progress on hair regrowth using Fin 1 mg/day for 4 years, Min 2x/day for 3 years, Estradiol 4mg/day, and Spironolactone 100mg/day for 3.5 months. They noted significant hairline recovery and advised against HRT for cis men due to feminizing effects.

Related Research

3 / 3 results

research Scalp Hair Regrowth in Alopecia Areata Patients Treated With Baricitinib: Early, Gradual, and Late Responders

November 2023 in “British Journal of Dermatology”

Different people with severe hair loss respond to baricitinib treatment at different times, with some showing improvement early, some gradually, and others later.

research Evaluation of Scalp Hair Density and Diameter in the Arab Population: Clinical Office-Based Phototrichogram Analysis

1 citations, December 2022 in “Clinical, cosmetic and investigational dermatology”

Arab hair is generally thicker but less dense compared to other ethnicities, affecting hair disorder diagnosis and treatment.

research Scalp Hair Diameter Increases During Pregnancy

34 citations, August 2003 in “Clinical and Experimental Dermatology”

Pregnant women's hair gets thicker.