Pigmentary Mosaicism: An Update

The document provided an update on pigmentary mosaicism, a condition characterized by skin manifestations such as hypo- or hyperpigmented lesions along Blaschko's lines. It was understood that these pigmentary abnormalities might be due to chromosomal mosaicism, where individuals have genetically different cell populations. The condition could involve multiple systems, with phenotypic expressions primarily in the dermal and musculoskeletal systems. Common features included hair and nail abnormalities, eye defects, skeletal anomalies, and mental retardation. Familial occurrences were noted, suggesting a possible genetic link. No definitive treatment existed, but systemic examinations were recommended to detect additional abnormalities, and seizures were to be managed with antiepileptics.