Peripilar Sign in Androgenetic Alopecia: Does It Really Indicate Peripilar Infiltrate?

    January 2024 in “Dermatology practical & conceptual
    Douglas Reis Abdalla, Manal Bosseila, Mona R. E. Abdel‐Halim, Iman Sany
    TLDR The Peripilar sign does not indicate perifollicular infiltrate in hair loss from Androgenetic Alopecia.
    The study "Peripilar Sign in Androgenetic Alopecia: Does It Really Indicate Peripilar Infiltrate?" involved 100 patients with Androgenetic Alopecia (AGA). The researchers aimed to assess the validity of the Peripilar sign (PPS) as an indicator of perifollicular infiltrate (PFI). The study found that PPS was present in 50% of the cases, but there was no significant difference in PFI between patients with and without PPS. The PPS was more common in patients with skin type III and its absence was significantly associated with lower interpretability of yellow dots. The study concluded that PPS does not reflect PFI in AGA. Instead, it represents a dark color more frequently seen in patients with lighter skin types, possibly due to the increased contrast between the dark PPS and the lighter surrounding skin. Further studies are needed to verify the cause of this peri-follicular dark color.
    View this study on dpcj.org →