Pediatric Ewing's Sarcoma and Permanent Chemotherapy-Induced Alopecia: A Case-Control Study

This study investigates permanent chemotherapy-induced alopecia (PCIA) in pediatric patients with Ewing's sarcoma (ES). A retrospective chart review of 12 pediatric ES patients revealed that 3 were diagnosed with PCIA, characterized by hair loss persisting for more than 6 months after chemotherapy. The study compared demographic factors, cumulative chemotherapy dosing, family history of hair loss, and treatment methodologies with a control group. The findings indicate that PCIA can occur in pediatric ES patients, and while treatments such as topical and oral minoxidil may be beneficial, they may not lead to complete hair regrowth.