215 citations
,
November 2000 in “Journal of Investigative Dermatology” The system allows precise control of gene expression in mouse skin, useful for studying skin biology.
149 citations
,
July 2000 in “Molecular and Cellular Biology” Keratin 6a is important for quick wound healing from hair follicles.
147 citations
,
April 1997 in “Oncogene” 25 citations
,
September 1995 in “Biochemistry and Cell Biology” High levels of human keratin 16 in mice cause skin lesions and abnormal skin development.
198 citations
,
November 1989 in “The Journal of Cell Biology” The study examined the expression of keratin K14 in human skin, particularly in the epidermis and hair follicles, using monospecific antisera and cRNA probes. It was found that K14 expression and filament organization differed significantly between the hair follicle and epidermis. In the outer root sheath (ORS) cells, which are mitotically active, K14 expression was low, and keratin filaments were fewer and more loosely organized compared to basal epidermal cells. As ORS cells differentiated, they increased K14 expression and formed denser keratin bundles. In contrast, matrix cells, which can differentiate into the inner root sheath, cuticle, and hair shaft, did not express K14 or form keratin filaments. Instead, they produced hair-specific keratins and dense filament bundles without inducing K14 expression. The study suggested that the patterns of K14 expression and filament organization in skin epithelial cells were linked to their pluripotency and highlighted the distinct differentiation programs of hair follicles compared to other stratified squamous epithelia.