Low Dose Oral Minoxidil vs Topical Minoxidil for Androgenetic Alopecia: Systematic Review and Meta-Analysis of Randomized Controlled Trials

September 2025 in “ Journal of the American Academy of Dermatology ”

Cristina Sicorschi Gutu, Amanda Scrobot Handocha, Andrés Noyola‐Perez, Luana Miyahira Makita, Mariana Tainá Oliveira de Freitas, Alexandra delaO-Escamilla

oral minoxidil topical minoxidil androgenetic alopecia hair density FDA-approved Rogaine

TLDR Low-dose oral minoxidil may be a promising alternative to topical minoxidil for hair loss.

This systematic review and meta-analysis evaluated the efficacy of low-dose oral minoxidil compared to topical minoxidil in treating androgenetic alopecia. The study aimed to determine which form of minoxidil is more effective in increasing hair density. While low-dose oral minoxidil is considered a promising off-label alternative, the research sought to establish its efficacy and safety relative to the FDA-approved topical version. The findings contribute to understanding the potential of oral minoxidil as a treatment option for androgenetic alopecia, although specific results and participant numbers were not detailed in the summary provided.

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in Minoxidil 92 upvotes 5 years ago

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