Oral Isotretinoin Therapy and Milia Formation in Patients with Acne Vulgaris: A Prospective Study

January 2021 in “ Journal of dermatology & dermatologic surgery ”

Ahmad AlAmari, Fahad Alsaif, Abdulrhman AlDakhil, Nourah AlSyefi, AlBatool AlAmari, Faisal Alsaif, Hend M Alotaibi, Amal Balbeesi, Nora AlBabtain

oral isotretinoin isotretinoin therapy milia acne vulgaris Accutane

TLDR Oral isotretinoin does not cause milia in acne patients.

The study investigated whether oral isotretinoin therapy at a standard dose of 0.5 mg/kg/day caused milia formation in patients with moderate-to-severe acne vulgaris. Fifty-one patients aged 18-25 years were assessed over 8 months. The results showed that none of the patients developed milia during the treatment period. The study concluded that there was no association between oral isotretinoin at the given dose and milia formation, suggesting that milia is at worst an uncommon side effect of isotretinoin therapy. Further research with higher doses of isotretinoin was recommended to explore this potential side effect more thoroughly.

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research Adverse Effects of Isotretinoin: A Retrospective Review of 1743 Patients

121 citations, June 2010 in “Australasian Journal of Dermatology”

Most people on isotretinoin had chapped lips, but only a few stopped the medicine due to side effects.

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research Oral Isotretinoin Therapy and Milia Formation in Patients with Acne Vulgaris: A Prospective Study

1 citations, January 2021 in “Journal of dermatology & dermatologic surgery”

Oral isotretinoin does not cause milia in acne patients.