A Longitudinal Examination of Nutritional-Inflammatory Biomarker Associations With Cancer-Related Cognition, Treatment Side Effects, and Quality of Life in Newly Diagnosed Older Adults Undergoing Chemotherapy
April 2025
in “
Cancer Research
”
Studysummary This study examined older adults undergoing chemotherapy and found that nutritional-inflammatory biomarker ratios were significantly linked to cognitive impairments, treatment side effects, and quality of life indicators, suggesting these lab measurements might help identify high-risk individuals for intervention.
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This study investigated the associations between nutritional-inflammatory biomarkers (NPAR, NLR, PLR, MLR) and cognitive function, treatment side effects, and quality of life in 144 newly diagnosed older adults undergoing chemotherapy. Significant associations were found between these biomarkers and cognitive impairment, emotional distress, and various chemotherapy-related symptoms such as hair loss, numbness, and nausea. The findings suggest that these easily obtainable lab ratios could serve as valuable prognostic tools for assessing and potentially mitigating treatment-related effects in high-risk individuals.
