Novel genes and variants associated with longevity in Bulgarian centenarians revealed by whole exome sequencing DNA pools: a pilot study

    January 2020 in “ Journal of Translational Genetics and Genomics ”
    Dimitar Serbezov, Lubomir Balabanski, Sena Karachanak-Yankova, Radoslava Vazharova, Desislava Nesheva, Zora Hammoudeh, Rada Staneva, Marta Mihaylova, Vera Damyanova, Olga Antonova, Dragomira Nikolova, Savina Hadjidekova, Draga Toncheva
    TLDR Certain genes may help Bulgarians live longer.
    The study aimed to identify genetic loci associated with longevity by analyzing whole exome sequencing data from Bulgarian centenarians compared to a control group. The researchers conducted a pilot study using DNA pools, which allowed them to efficiently screen for novel genes and variants linked to extended lifespan. The findings suggested that certain genetic factors might contribute to longevity in the Bulgarian population, although the study was preliminary and required further validation with larger sample sizes to confirm these associations.
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