NFAT5 mediates hypertonic stress-induced atherosclerosis via activating NLRP3 inflammasome in endothelium

    August 2019 in “ Cell Communication and Signaling ”
    Pingping Ma, Shenfang Zha, Xinkun Shen, Yulan Zhao, Li Li, Li Yang, Mingxing Lei, Wanqian Liu
    TLDR NFAT5 triggers atherosclerosis under stress by activating inflammation in blood vessels.
    The study identified NFAT5 as a crucial transcription factor necessary for the early activation of the NLRP3 inflammasome, which mediated innate immunity in the endothelium. This process contributed to the development of atherosclerosis when induced by hypertonic stress.
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