Natural Pathogens of Laboratory Animals and Their Effects on Research

The document discussed the natural fungal pathogens affecting laboratory animals like rabbits and guinea pigs, primarily dermatophytes such as Trichophyton mentagrophytes, and less frequently Microsporum gypseum and M. canis. These infections were rare in well-managed facilities but more common in young or immunocompromised animals, causing skin issues that could interfere with histological studies. Yeast infections from Candida spp. were occasionally reported. The paper also examined the impact of these pathogens on research, particularly in the context of evaluating topical antifungal agents and the effects of immunosuppression, which could lead to severe pneumocystosis in mice and rats, making them unsuitable for experiments.