Clinical Presentation and Diagnosis of Multisystemic Eosinophilic Epitheliotropic Disease in a Miniature Donkey: A Case Report

    June 2025 in “ Journal of Veterinary Internal Medicine ”
    Carla Katherine Enriquez, Alicia E. Long, Cristobal Navas de Solís, Perry L. Habecker, Rose Nolen‐Walston
    TLDR The donkey had a severe disease affecting multiple organs and was euthanized.
    This case report details a 21-year-old miniature donkey diagnosed with Multisystemic Eosinophilic Epitheliotropic Disease (MEED), a rare and chronic condition marked by eosinophil infiltration in multiple organs. The donkey exhibited symptoms such as pruritus, alopecia, inappetence, and hypertriglyceridemia, with increased liver enzyme activities. Despite treatment, the condition deteriorated, resulting in euthanasia. Necropsy showed significant eosinophilic inflammation in organs like the liver, heart, and pancreas. MEED is usually seen in younger horses, but this case underscores its occurrence in older donkeys and its progressive nature. The prognosis is poor, and while corticosteroid treatment is debated due to potential complications, the disease's pathogenesis remains unclear, necessitating further research for better understanding and treatment options.
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