Decision Letter: A Multi-Scale Model for Hair Follicles Reveals Heterogeneous Domains Driving Rapid Spatiotemporal Hair Growth Patterning

The study used a multi-scale model to investigate hair growth patterns in mice, revealing that hair regeneration rates varied across different anatomical sites, with faster regeneration in the chin and ventral skin compared to the dorsal skin, and very slow regeneration in the ear skin. This suggested that the skin acted as a complex regenerative landscape. The research highlighted the universal role of WNT/BMP signaling in hair growth across all skin regions, challenging previous studies focused on dorsal skin. The study found that non-skin tissues with WNT/BMP expression could influence hair regeneration, as seen in the mouse ear. The findings suggested that similar regenerative features might exist in other tissues and organs, potentially guiding future research in regenerative medicine. The study's modeling approach was refined to address reviewer concerns, ensuring consistency with experimental observations.