Monilethrix In Monozygotic Twins With Very Rare Mutation In KRT 86 Gene

March 2017 in “ Journal of the European Academy of Dermatology and Venereology ”

Bogusław Nedoszytko, Zuzanna Lewicka-Potocka, Aneta Szczerkowska‐Dobosz, Jolanta Gleń, Barbara Bykowska, J. Świątecka – Czaj, Roman Nowicki

monilethrix KRT 86 gene hair keratin genes autosomal dominant mutations alopecia

TLDR Identical twins with a rare KRT 86 gene mutation both have the hair disorder monilethrix.

The study discussed a case of monilethrix in monozygotic twins with a very rare mutation in the KRT 86 gene. Monilethrix is a hereditary disorder affecting hair shafts, typically due to autosomal dominant mutations in hair keratin genes. The condition can vary significantly among affected individuals, ranging from nearly normal scalp hair to alopecia, and its severity may change over a person's lifetime. This particular case highlighted the genetic basis of the disorder and its manifestation in identical twins.

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