Molecular mechanisms of androgen receptor functions

The document explored the molecular mechanisms of androgen receptor (AR) functions, focusing on the roles of testosterone (T) and dihydrotestosterone (DHT) in male sex organ development and prostate cancer growth. It discussed how non-metastatic prostate tumors were treated with radiotherapy or surgery, while metastatic prostate cancer treatment aimed to inhibit androgen action through chemical castration and anti-androgens. The AR, a nuclear receptor, acted as a ligand-induced transcription factor in androgen target cells. The research highlighted various aspects of AR functions, including receptor structure, protein interactions, ligand-dependent N/C interaction, androgen-specific gene expression, and AR mutations in prostate cancer.