The Mexican Hairless Dog as a Model for Assessing the Comedolytic and Morphogenic Activity of Retinoids
January 1996
in “
British journal of dermatology/British journal of dermatology, Supplement
”
New to Tretinoin? There is a guide in the encyclopedia. Read the guide → Studysummary This study found that treating the skin of Mexican hairless dogs with different tretinoin formulations reduced comedones and lightened skin color, suggesting its potential as a model for evaluating retinoid activity.
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The study used the Mexican hairless dog, which naturally has comedones, to evaluate the comedolytic activity of three different formulations of tretinoin over 14 weeks. All formulations significantly reduced the number of comedones and improved skin color uniformity. Histological changes were consistent with those seen in humans treated with tretinoin, and a novel observation was the incomplete neogenesis of hair follicles. The researchers concluded that the Mexican hairless dog could serve as a valuable model for screening new retinoid compounds.
