Methotrexate Treatment of Generalized Granuloma Annulare: A Retrospective Case Series

The study evaluated the efficacy and adverse effects of methotrexate in treating generalized granuloma annulare (GGA) through a retrospective case series of 11 patients. Results showed that 64% of patients experienced improvement, with 43% achieving complete clearance and 57% partial clearance. Methotrexate doses ranged from 12.5 to 15 mg weekly, administered orally or subcutaneously. Most patients tolerated the treatment well, though 18% experienced adverse effects such as gastrointestinal upset or hair loss. Despite the lack of a control group and precise measurement tools, the study concluded that methotrexate could be a successful and well-tolerated treatment option for GGA.